Chungnam National University. Graduate School of New Drug Discovery and Development.

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이병호교수
전공분야신약개발/약리학
교수실한국화학연구원, 신약기반기술연구센터, 6연구동 101호 (042-860-7415)
실험실심장순환계약리연구실 (042-860-7402)
이메일bhlee@krict.re.kr
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학력 (Education)

학사: 1981~1985, 중앙대학교 약학과 
석사: 1985~1987, 중앙대학교 약학과 약물학 전공 
박사: 1990~1993, 중앙대학교 약학과 약물학 전공

 

 

경력 (Professional Experience)

1985~1988: 국제약품 
1988~현재한국화학연구원책임연구원 
1995~1996: 미국 Cincinnati 대학교의과대학 Post Dr.
1999~2003: 충남대학교약학대학겸임교수 
2010~현재충남대학교신약전문대학원학연교원

 

 

주요 연구 활동

 1. 심혈관 질환 치료제 개발

심부전 치료제 개발 (UT 수용체, ROCK II )

허혈성 혈관질환 치료제 개발

Drug repositioning 기술을 이용한 신약개발 활용 시스템 구축 (심혈관 질환)

2. 약리활성 평가기술

약리활성 평가기술을 활용한 글로벌 신약개발 연구

High throughput screening 기반시설을 활용한 약효검색

심순환계 부작용 평가기술

 

 

대표 논문

Oh KS, Lee S, Choi JK, Lee BH, Identification of novel scaffolds for IκB kinase beta inhibitor via a high-throughput screening TR-FRET assay, Comb. Chem. High Throughput Screen., 13:790-797 (2010)


Nagarajan S, Choo H, Cho YS, Oh KS, Lee BH, Shin KJ, Pae AN, IKKβ inhibitors identification: Multi filter driven novel scaffold, BMC Bioinformatics, 11(Suppl 7): S15 (2010)


 Kim SY, Choi YJ, Joung SM, Lee BH, Jung YS, Lee JY, Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor, Immunology, 129: 516-524 (2010)


Oh BK, Oh KS, Kwon K, Yoo SY, Kim YS, Lee BH, Melanin-concentrating hormone-1 receptor antagonism of pheophorbides isolated from Morus Alba leaves, Phytother. Res., 24: 919-923 (2010)


Nagarajan S, Choo H, Cho YS, Oh KS, Lee BH, Shin KJ, Pae AN, IKKβ inhibitors identification part II: Ligand and structure-based virtual screening, Bioorg. Med. Chem., 18:3951-3960 (2010)


Oh KS, Lee S, Yi KY, Seo HW, Koo HN, Lee BH, A novel and orally active poly (ADP-ribose) polymerase-1 inhibitor, 2-[methoxycarbonyl (4-methoxyphenyl)methyl sulfanyl]-1H- benzimidazole-4-carboxylic acid amide (KR-33889), attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia, J. Pharmacol. Exp. Ther., 328: 10-18 (2009)


Lee S, Yi KY, Yoon SJ, Lee BH, Yoo SE, (2-Aryl-4-methylimidazol-5-ylcarbonyl) guanidines as NHE-1 inhibitors, Bioorg. Med. Chem. Lett., 19:1329-1331 (2009)


Lee MJ, You KR, Lee BH, Kwak YK, Kim DG, Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion Injury, Exp. Mol. Med., 41:243-252 (2009)

 

Oh KS, Ryu SY, Lee S, Seo HW, Oh BK, Kim YS, Lee BH , Melanin-concentrating hormone-1 receptor antagonism and anti-obesity of ethanolic extract from Morus Alba in diet-induced obese mice, J. Ethnopharmacol., 122: 216-220 (2009) 

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