Chungnam National University. Graduate School of New Drug Discovery and Development.

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구태성교수
전공분야약동학
교수실신약전문대학원 421호 (042-821-8628)
실험실약동학 실험실 (042-821-8633)
이메일kootae@cnu.ac.kr
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학력 (Education)

 학사: 1994~1998 서울대학교 제약학과 

 석사: 1998~2001 서울대학교 대학원 약학과

 박사: 2001~2005 서울대학교 대학원 제약학과

 

 

경력 (Professional Experience)

 2005~2012: SK바이오팜 책임연구원

 2010~2012: 충남대학교 약학대학 겸임조교수

 2012~현재충남대학교 신약전문대학원 부교수

 

 

주요 연구 활동   

 Pharmacokinetics in rodent and non-rodent

 In vitro Screening of Drug ADME (Absorption, Distribution, Metabolism and Excretion)

 Drug interaction involving hepatic metabolism

 Bioanalytical method development using mass spectrometry

 

 

대표논문

SM Kim, JW Jeong, A Nam, KH Song, TS Koo*, KW Seo*. Comparison of Body Surface Area-Based and Weight-Based Dosing Format for Oral Prednisolone Administration in Small and Large-Breed Dogs. Polish J Vet Sci. 2017; Accepted

 

KR Lee1, JW Jeong1, HC Hyun, E Jang, S Ahn, S Choi, SH Joo, SS Kim*, TS Koo*. Pharmacokinetics of Tafamidis, a Transthyretin Amyloidosis Drug, in Rats. Xenobiotica. 2017; DOI: 10.1080/00498254.2017.1366575 [Epub ahead of print]

 

JW Chae, HY Yun, HY Eom, E Jeong, TS Koo, KI Kwon, JH Lee*. Development of a LCMS/MS Method for the  Determination of CKD-712 in Rat Plasma: Application to a pharmacokinetic Study in Rats. J Chromatogr B. 2017; DOI: 10.1016/j.jchromb.2017.07.011 [Epub ahead of print]

 

Kim HR, JW Jeong, Joo SH*, TS Koo*. Effects of Angelica Gigas Extract on the Oral Pharmacokinetics of Gefitinib in Rats. J Pharm Inv. 2017; DOI: 10.1007/s40005-017-0315-y [Epub ahead of print]


 JW Jeong1, Seol YH1, HC Hyun, HR Kim, JH Lee, YD Gong, NS Kang, TS Koo*. A Validated HPLC-MS/MS Method for the Quantification of Supinoxin in Rat Plasma and Its Application to Pharmacokinetic Study. Acta Chromatogr. 2017; DOI: 10.1556/1326.2016.00056 [Epub ahead of print]

 
Hwang JH1, JW Jeong1, GH Song, TS Koo*, KW Seo*. Pharmacokinetics and Acid Suppressant Efficacy of Esomeprazole after Intravenous, Oral and Subcutaneous Administration to Healthy Beagle Dogs. J Vet Intern Med. 2017; 31: 743-750 

HC Hyun1, JW Jeong1, HR Kim, JH Oh, JH Lee, S Choi, YS Kim, TS Koo*. Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Assay of Tafamidis in Rat Plasma: Application to a Pharmacokinetic Study in Rats. J Pharm Biomed Anal. 2017; 137: 90-95 

 

Byun SY, JW Jeong, JH Choi, KP Lee, HY Youn, HJ Maeng, KH Song, TS Koo*, KW Seo*. Pharmacokinetic study of meropenem in healthy beagle dogs receiving intermittent hemodialysis. J Vet Pharmacol Ther. 2016; 39: 547-559 
 
JW Jeong1, Yu C1, Lee JH, Moon KS, Kim E, Yoo SE*, TS Koo*. Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson’s disease agent, after oral administration in rats and dogs. Regul Toxicol Pharmacol. 2016; 81: 387-396 
 

 B Kim, H Park, SK Lee, SJ Park, TS Koo, NS Kang, Hong KB*, Choi S*. Systemic Optimization and Structural Evaluation of 

 Quinoline Derivatives as Transthyretin Amyloidogenesis Inhibitors. 2016; Eur J Med Chem. 2016; 123: 777-787

JH Kim, TH Kim, HJ Park, YJ Choi, JH Kang, KH Song, TS Koo*, KW Seo*. The Pharmacokinetics of the β2-adrenoceptor Agonist, Tulobuterol, in Beagle Dogs Following Transdermal and Intravenous Administration. Vet J. 2016; 208: 90-92

 

TH Kim1, JW Jeong1, JH Song, KR Lee, S Ahn, SH Ahn, SS Kim*, TS Koo*. Pharmacokinetics of Enzalutamide, an Anti-Prostate Cancer Drug, in Rats. Arch Pharm Res. 2015; 38: 2076-2082

 

WD Jang, JT Kim, HY Son, SY Park, YS Cho, TS Koo, H Lee*, NS Kang*. Discovery of Tyk2 Inhibitors via the Virtual Site-Directed Fragment-Based Drug Design. Bioorg Med Chem Lett. 2015; 25: 3947-3952

 

CH Won, YM Jeong, S Kang, TS Koo, SH Park, KY Park, YK Sung and JH Sung*. Hair-Growth-Promoting Effect of  Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells. Int J Mol Sci. 2015; 16: 4379-4391

 

JH Song, TH Kim, JW Jung, N Kim, SH Ahn, SO Hwang, NS Kang, SE Yoo, TS Koo*. Quantitative Determination of Enzalutamide, an Anti-Prostate Cancer Drug, in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry, and Its Applications to Pharmacokinetic Study. Biomed Chromatogr. 2014; 28: 1112–1117

 

SJ Kim, DJ Ha, TS Koo*. Simultaneous Quantification of Methylene Blue and Its Major Metabolite, Azure B, in Plasma by LC-MS/MS and Its Application for a Pharmacokinetic Study. Biomed Chromatogr. 2014; 28: 518-524

 

BJ Ryu, N Kim, JT Kim, TS Koo, SE Yoo, SH Jeong, SH Kim, NS Kang*. Discovery of Non-LBD Inhibitor for Androgen Receptor by Structure-Guide Design. Bioorg Med Chem Lett. 2013; 23: 3887-3890

 

YJ Chae, TS Koo, KR Lee*. A Sensitive and Selective LC/MS Method for the Determination of Lurasidone in Rat Plasma, Bile, and Urine. Chromatographia. 2012; 75: 1117–1128

 

TS Koo, Kwon HJ, Kim MH, DD Kim, CK Shim, SJ Chung, SH Chong *, Functional Impairment of Rat Taurine Transporter by Activation of Nitrogen Oxide through Superoxide. Drug Metab Pharmacokinet. 2012; 27: 286-293

SJ Kim,
TS Koo*, DJ Ha, MK Baek, SK Lee, DS Shin, HS Moon. Liquid Chromatography-tandem Mass Spectrometry for Quantification of Lacosamide, an Antiepileptic drug, in Rat Plasma and Its Application to Pharmacokinetic Study. Biomed Chromatogr. 2012; 26: 371-376

TS Koo
, SJ Kim*, DJ Ha, MK Baek, HS Moon, Pharmacokinetics, Brain Distribution, and Plasma Protein Binding of the Antiepileptic Drug Lacosamide in Rats. Arch Pharm Res. 2011; 34: 2059-2064
 
KR Lee, YJ Chae, TS Koo*, Pharmacokinetics of Lurasidone, a Novel Atypical Antipsychotic Drug in Rats. Xenobiotica. 2011; 41: 1100-1107

TS Koo*, SJ Kim, JJ Lee, DJ Ha, MK Baek, HS Moon. Quantification of Lurasidone, an Atypical Antipsychotic Drug, in Rat Plasma with Highperformance Liquid Chromatography with Tandem Mass Spectrometry. Biomed Chromatogr. 2011; 25: 1389-1394
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