Chungnam National University. Graduate School of New Drug Discovery and Development.
교수진 소개
- 김성섭교수
- 전공분야생물의약/단백질신약개발
- 교수실신약전문대학원 422호 (042-821-8629)
- 실험실바이오의약실험실 (042-821-7334)
- 이메일sungsub@cnu.ac.kr
- 홈페이지
학력 (Education)
학사: 1982~1986서울대학교 미생물학과
석사: 1986~1988서울대학교 대학원 미생물학과
박사: 1990~1996Cornell University 분자생물학과 이학박사
경력 (Professional Experience)
1996~2000 : UC Berkeley Postdoc
2000~2007 : LG생명과학
Caspase Inhibitor 개발
간염치료제, Gilead에 Licensing-out 됨 (2억불 규모)
DPP-IV Inhibitor 개발
당뇨병 치료제, 2012년 식약청 판매 승인 (제미글립틴)
R&D 전략 과제발굴팀
회사 내 과제리뷰 및 발굴, 타 회사와 사업계약 체결
2008~2010 : 에이앤알쎄라퓨틱스
항체 치료제 개발 총괄(대표이사)
2010~2012 : 영인프런티어
항체치료제 및 항체진단키트 개발 총괄(본부장)
2012~ 현재 : 충남대학교 신약전문대학원 신약개발학과 교수
2015~2016: 충남대학교 산학협력단 부단장
2017~현재: 충남대학교 신약전무대학원 원장
주요 연구 활동
프런티어 사업 평가위원
생명공학연구원 평가위원
충청광역권 선도사업 기획 및 평가위원
한국의약바이오기업협의회 이사
전주기적 범부처 신약개발사업 기획위원
교과부 신약개발후보발굴과제 모니터 위원
연구재단 R&D 전문기획의원
대표논문
Sungsub Kim and Kenneth J Marians (1995). DNA and RNA-DNA annealing activity associated with the t subunit of the Escherichia coli DNA polymerase III holoenzyme. Nucleic Acid Res. 23, 1374-1379.
Sungsub Kim, H. Garry Dallman, Charles S. McHenry, and Kenneth J Marians (1996). Coupling of a replicative polymerase and helicase: A t-DnaB interaction mediates rapid replication fork movement. Cell 84, 643-650.
Sungsub Kim, H. Garry Dallman, Charles S. McHenry, and Kenneth J Marians (1996). t protects bin the leading-strand polymerase complex at the replication fork. J. Biol. Chem. 271, 4315-4318.
Sungsub Kim, H. Garry Dallman, Charles S. McHenry, and Kenneth J Marians (1996). tcouples the leading- and lagging-strand polymerases at the Escherichia coli DNA replication fork. J. Biol. Chem.271, 21406-21412.
H, Garry Dallman, Sungsub Kim, AE Pritchard, Kenneth J Marians, and Charles S. McHenry (2000). Characterization of the unique C terminus of the Escherichia coli tau DnaX protein. Monomeric C-t binds alpha AND DnaB and can partially replace t in reconstituted replication forks. J. Biol. Chem. 275, 15512-15519.
Seok Soon Park, Young-Woo Eom, Eun Hee Kim, Ji Hyun Lee, Do Sik Min, Sungsub Kim, Seong-Jin Kim, and Kyeong Sook Choi (2004). Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis. Oncogene 23, 6272-6281.
Ki Dong Koo, Min Jung Kim, Sungsub Kim, Kyoung-Hee Kim, Sang Yong Hong, Gwong-Cheung Hur, Hyeon Joo Yim, Geun Tae Kim, Hee Oon Han, O Hwan Kwon, Tae Sik Kwon, Jong Sung Koh and Chang-Seok Lee (2007). Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones. Bioorg. Med. Chem. Lett. 17, 4164-4172
Kim DM, Chu SH, Kim S, Park YW, Kim SS (2009). Fc fusion to glucagon-like peptide-1 inhibits degradation by human DPP-IV, increasing its half-life in serum and inducing a potent activity for human GLP-1 receptor activation. BMB Rep. 42, 212-216.
Jeon B, Kim BH, Lee YS, Kim S, Yoon JB, Kim TY (2011). Inactive extracellular superoxide dismutase disrupts secretion and function of active extracellular superoxide dismutase. BMB Rep. 44, 40-45.
Sung Ah Moon, Min Kyung Ki, Sungyoung Lee, Mi-Lim Hong, Misook Kim, Sungsub Kim, Junho Chung, Sue Goo Rhee, Hyunbo Shim (2011). Antibodies against non-immunizing antigens derived from a large immune scFv library. Molecules and Cells 31, 509-513.
Jeon YJ, Yoo H, Kim BH, Lee YS, Jeon B,Kim SS, Kim TY (2012). IFNγ-mediated inhibition of cell proliferation through increased PKCδ-induced overexpression of EC-SOD. BMB Rep. 45, 659-664.