Chungnam National University. Graduate School of New Drug Discovery and Development.

교수진 소개

HOME교수 및 연구활동교수진 소개

최성욱

최성욱교수
전공분야의약화학/생유기분자합성
교수실신약전문대학원 418호 (042-821-8625)
실험실유기체합성실험실 433호 (042-821-7332)
이메일swchoi2010@cnu.ac.kr
홈페이지
목록으로

학력 (Education)

학사: 1991~1998 충남대학교 화학과

석사: 1998~2000 연세대학교 화학과

박사: 2001~2006 University of Pennsylvania 화학과


경력 (Professional Experience)

2006 ~ 2010 : The Scripps Research Institute Post Doc.

2010 ~ 현재 : 충남대학교 신약개발학과 부교수

2016 ~ DRC 학연공동연구센터

 

주요 연구 활동

Transthyretin 단백질의 아밀로이드 형성 저해제 개발 연구

알츠하이머병 진단 용 transthyretin 형광 프로브 개발 연구

카이나아제 저해제 개발연구

 

대표 논문

Connelly, S.; Mortenson, D. E.; Choi, S.; Wilson, I. A.; Powers E. T.; Kelly, J. W.; Johnson, S. M. Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors Bioorg. Med. Chem. Lett. 2017, 27, 3441.

Hyun, H. C.; Jeong, J. W.; Kim, H. R.; Oh, J. H.; Lee, J. H.; Choi, S.; Kim, Y. S.; Koo, T. S. Development and validation of a liquid chromatography-tandem mass spectrometry method for the assay of tafamidis in rat plasma: Application to a pharmacokinetic study in rats. J. Pharm. Biomed. Anal. 2017, 137, 90.


 Lee, E. J.; Pokharel, S.; Jan, A. T.; Huh, S.; Galope, R.; Lim, J. H.; Lee D.; Choi, S.; Nahm, S.; Kim, Y.; Park S.; Choi, I. Transthyretin: A Transporter Protein Essential for Proliferation of Myoblast in the Myogenic Program. International Journal of Molecular Sciences 2017, 18, 115.

Kim, B.; Park, H.; Lee, S. K.; Park, S. J.; Koo, T.; Kang, N. S.; Hong K. B.; Choi, S. Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors. European Journal of Medicinal Chemistry 2016, 123, 777.


Jung J.; Lee, N.; Park, H. Park, S. J.; Choi, S. Design and Evaluation of Quinolone Derivatives as Potent Inhibitors of Wild-type TTR and V30M TTR Amyloidogenesis Bulletin of the Korean Chemical Society 2015, 36, 719


Kim B.; You, S.; Lee, N.; Choi, S. Efficient Synthesis of Unsymmetrical 1,3-Diynes Utilizing a Palladium-Catalyzed Cross-Coupling Reaction Without Homo-Coupling Bulletin of the Korean Chemical Society 2015, 36, 360


Baranczak, A.; Connelly, S. P.; Liu, Y.; Choi, S.; Grimster, N. P.; Powers, E. T.; Wilson, I. A.; Kelly, J. W. Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn. Biopolymers 2014, 101,484


Myung, N.; Connelly, S.; Kim, B.; Park, S. J.; Wilson, I. A.; Kelly, J. W.; Choi, S. Bifunctional coumarin derivatives at inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chem. Commun. 2013, 49, 9188.


Mensa, B.; Kim, Y.; Choi, S.; Scott, R.; Caputo, G. A.; DeGrado, W. F. Antibacterial Mechanism of Action of Arylamide Foldamers. Antimicrobial agents and chemotherapy 2011, 55, 5043.


Bourgault, S.; Choi, S.; Buxbaum, J. N.; Kelly, J. W.; Price, J. L.; Reixach, N. Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochem. Biophys. Res. Commun. 2011, 410, 707.


Choi, S.; Kelly, J. W. Competition Assay to Identify Amyloidogenesis Inhibitors by Monitoring the Fluorescence Emitted by the Covalent Attachment of a Stilbene Derivative to Transthyretin. Bioorg. Med. Chem. 2011, 19, 1505.


Choi, S.; Ong D. S. T.; Kelly, J. W. A Stilbene That Binds Selectively to Transthyretin in Cells and Remains Dark until It Undergoes a Chemoselective Reaction To Create a Bright Blue Fluorescent Conjugate. Journal of the American Chemical Society 2010, 132, 16043.

 

Connelly, S.; Choi, S.; Johnson, S.; Kelly, J. W.; Wilson, I. A. Structure-Based Design of Kinetic Stabilizers that Ameliorate the Transthyretin Amyloidoses. Current Opinion in Structural Biology 2010, 20, 54.

 

Choi, S.; Reixach, N.; Connelly, S.; Johnson, S.; Wilson, I. A.; Kelly, J. W. A Substructure Combination Strategy to Create Potent and Selective Transthyretin Kinetic Stabilizers that Prevent Amyloidogenesis and Cytotoxicity. Journal of the American Chemical Society 2010, 132, 1359.

 

Choi, S.; Connelly, S.; Reixach, N.; Wilson, I. A.; Kelly, J. W. Chemoselective Small Molecules that Covalently Modify One Lysine in a Non-enzyme Protein in Plasma. Nature Chemical Biology 2010, 6, 133.

 

특허

1. DeGrado, W. F.; Liu, D.; Tew, G. N.; Klein, M. L.; Yuan, J.; Choi, S. Facially Amphiphilic Polymers and Oligomers and Uses Thereof. 2013, US 8455,490 B2. (미국)

 

2. Kelly, J. W.; Choi, S. Small molecules that covalently modify transthyretin. 2012, US20120270938 A1 (미국)

 

3. DeGrado, W. F.; Bennett, J. S.; Snyder, S. E.; Choi, S. Inhibitors of the alpha2beta1/ GPIA-IIA integrin. 2012, US 8258,159 B2. (미국)

비밀번호 입력
비밀번호
확인
비밀번호 입력
비밀번호
확인